With the advancement of global socio-economic development, the conservation and regeneration of architectural heritage have become a critical issue of worldwide concern. Artistic intervention, as an innovative approach, plays an indispensable catalytic role in revitalizing heritage spaces through adaptive reuse. However, existing research remains limited, predominantly confined to theoretical discussions and lacking in-depth integration with practical dimensions. This study adopts Shanghai's Rong Zhai as a research case to explore how art reconstructs pathways for architectural heritage renewal, promoting the synergistic development of cultural continuity and spatial regeneration. Through an analysis of PRADA Rong Zhai's artistic programs, it is evident that artistic participation not only acts as a catalyst for functional revitalization and economic rejuvenation but also serves as a medium for constructing public engagement and enhancing the contemporary social value of architectural heritage. Compared to traditional conservation models that emphasize material authenticity as a singular priority, the art-mediated regeneration strategy proposes a novel conceptualization for architectural heritage:On one hand, it transforms heritage from static objects of preservation into dynamic participatory social processes;On the other hand, it coordinates the transmission of cultural memory with the demands of spatial transformation through multidimensional synergies encompassing spatial optimization, cultural dissemination, and community participation. The balancing mechanism established by PRADA Rong Zhai between historical preservation and contemporary innovation provides a practical reference for global cities, offering new possibilities to address the structural contradictions between maintaining historical identity and fostering future-oriented urban innovation.