Traditional image mosaic method usually generates the mosaic visual effects for the whole input image. In this paper, we propose a general framework to automatically generate mosaic in the saliency region of the input image for the protection of privacy information. Firstly, a feature-preserving image mosaic method by edge-weighted centroidal voronoi tessellations (EWCVT) is proposed. Secondly, by combining the proposed feature-preserving image mosaic method and the saliency detection method, a salience-driven image mosaic framework is presented. Experimental results show the effectiveness of our algorithm, and the boundary of the mosaic area in the generated mosaic image captures the shape of salient regions. In particular, mosaic tessellations are neatly arranged thanks to edge-weighted centroidal Voronoi tessellation. The proposed framework can be used for the image privacy information protection and artistic applications.